The Daily Index — Tuesday, March 25, 2025 · TLDR Index

Across today’s newsletters

Today’s Index

TLDR

GOOGLE IS SEARCHING FOR AN ANSWER TO CHATGPT

Google's search engine is one of the most profitable technologies ever developed, and there's little evidence that this is changing, but the company is acting with urgency, focusing on generative AI efforts. Multiple independent web publishers say their traffic has been falling as Google's AI overviews present information directly on Google's own results pages. The relationship between Google and publishers is tense - Google is framing it as a broad conversation about the changing nature of search. Big changes are coming to Search, and the web may never be the same.

bloomberg.com · 32 min

TLDR AI

INTRODUCING TOGETHER CHAT: USE DEEPSEEK R1 FOR FREE, HOSTED IN NORTH AMERICA

Together Chat has launched a free consumer app that offers seamless interaction with top open-source models, including the new DeepSeek R1 for advanced reasoning. It supports web crawling, code generation with Qwen Coder 32B, and image creation using Flux Schnell, all accessible via a Progressive Web App.

together.ai · 3 min

TLDR Web Dev

TYPESCRIPT MIGRATES TO GO: WHAT'S REALLY BEHIND THAT 10X PERFORMANCE CLAIM?

Microsoft recently announced the porting of the TypeScript compiler from JavaScript to Go, promising a 10x performance improvement. However, the performance increase applies specifically to the compilation process, not the execution speed of TypeScript code itself. The shift to Go allows for better utilization of concurrency through goroutines, addressing the limitations of JavaScript's single-threaded event loop, which struggles with CPU-intensive tasks like compiling.

architecture-weekly.com · 22 min

TLDR InfoSec

AUTHENTICATION BYPASS IN NEXT.JS

Next.js has disclosed a Critical (9.1/10) auth bypass vulnerability. Next.js uses an internal header, X-middleware-subrequest, to prevent infinite loops from recursive requests. The vulnerability allowed users to abuse the header, bypassing middleware checks, including authorization.

nextjs.org · 2 min

TLDR Crypto

FIDELITY FILES FOR ETHEREUM-BASED US TREASURY FUND ‘ONCHAIN'

Fidelity plans to register a tokenized version of its US Treasury Digital Fund, “OnChain,” on Ethereum for improved transparency and tracking. While the blockchain will serve as a secondary, reconciled record of share ownership, official records will continue to be maintained via traditional book-entry systems. If approved, it is expected to go live on May 30. The $80 million fund is primarily composed of US Treasury bills.

cointelegraph.com · 3 min

TLDR

GENETIC TESTING COMPANY 23ANDME DECLARES BANKRUPTCY

23andMe has entered Chapter 11 bankruptcy and has asked a court to arrange its sale. The company's entire board resigned back in September due to a conflict between its board about future directions - the company has been losing money for years. There is enough funding to continue operations until a buyer is found. The pending sale has raised significant privacy concerns. The US prevents the use of genetic data for use in health insurance and employment decisions, but plenty of other uses are still legal, and customers outside of the US may have far fewer protections.

arstechnica.com · 2 min

TLDR

ELI LILLY WILL SOON RELEASE KEY DATA ON ITS WEIGHT LOSS PILL. HERE'S WHY IT COULD BE A GAME-CHANGER

Eli Lilly expects to unveil data from several late-stage clinical trials on its experimental once-daily obesity pill this year. Orforglipron is predicted to be as effective, safe, and tolerable to take as semaglutide. The pill targets GLP-1 to suppress appetite and regulate blood sugar. It is unclear whether the pill will have a hefty price similar to current GLP-1 injections, which cost roughly $1,000 per month. The pill could receive US regulatory approval as soon as early 2026.

cnbc.com · 13 min

TLDR

NEW CRISPR TOOL ENABLES MORE SEAMLESS GENE EDITING — AND IMPROVED DISEASE MODELING

Scientists at Yale have developed a series of sophisticated mouse models using CRISPR technology that can simultaneously assess genetic interactions on a host of immunological responses to multiple diseases, including cancer. The new tool, CRISPR-Cas12a, can induce and track changes in a variety of immune system cells in response to gene editing and fine-tune sets of genes in different directions simultaneously. It enables the rapid generation of new disease and treatment models. The tool will be valuable to researchers creating therapies for a host of pathologies, including cancer, metabolic disease, autoimmune disease, and neurological disorders.

news.yale.edu · 3 min

TLDR

LEDGER IMPLEMENTATION IN POSTGRESQL

pgledger is a financial ledger implementation implemented entirely in PostgreSQL. It makes it easy to view the history to understand why an account balance is at its current value and query for a historical value at a given time. pgledger uses just functions and tables so users can have the full power of PostgreSQL and avoid integrating with any new APIs or run any new services.

pgrs.net · 4 min