NEW CRISPR TOOL ENABLES MORE SEAMLESS GENE EDITING — AND IMPROVED DISEASE MODELING

Summary from the TLDR newsletter

Scientists at Yale have developed a series of sophisticated mouse models using CRISPR technology that can simultaneously assess genetic interactions on a host of immunological responses to multiple diseases, including cancer. The new tool, CRISPR-Cas12a, can induce and track changes in a variety of immune system cells in response to gene editing and fine-tune sets of genes in different directions simultaneously. It enables the rapid generation of new disease and treatment models. The tool will be valuable to researchers creating therapies for a host of pathologies, including cancer, metabolic disease, autoimmune disease, and neurological disorders.