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THE DAILY INDEX

Technology, AI, software, security, crypto and business

MISCELLANEOUS

TLDR

WHERE ARE ALL THE TRILLION DOLLAR BIOTECHS?

The drug development industry addresses the most tractable diseases with the biggest outcomes first. However, unlike with other industries, reinvesting capital from early wins back into the ecosystem hasn't accelerated the industry's progress - it has been on a reverse trend for a while now. For the industry to advance, manufacturing and trials need to get cheaper with each run, regulations should become more adaptive, approval frameworks should increase and not decrease in variance, and new therapeutic modalities should focus on unlocking new biology. Until these new paradigms take hold, it will be difficult to build a trillion-dollar biotech.

THOUGHTS ON (AMAZONIAN) LEADERSHIP

Amazon's Leadership Principles are famous in the tech world. They're generally sensible rules by which to run a company. The principles include Customer Obsession, starting with the customer and working backwards; Ownership, thinking long term that not sacrificing long-term value for short-term results and acting on behalf of the company, not just your own team; and Bias for Action, making fast decisions and being aware that many decisions and actions are reversible and do not need extensive study. This article provides some commentary on these principles.

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