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THE DAILY INDEX

Technology, AI, software, security, crypto and business

Across today’s newsletters

Today’s Index

INSTITUTIONS TRIM BTC WHILE SOLANA ETFS KEEP ABSORBING FLOWS

BlackRock's IBIT posted a record $523 million single-day outflow and has now seen $1.43 billion pulled over five days and $2.19 billion over four weeks, as institutions rebalance risk since bitcoin's slide from a $126,080 ATH and ongoing Fed rate and liquidity uncertainty. The selling drove a $372.7 million net outflow across all spot BTC ETFs and similar redemptions from ETH products. Spot Solana ETFs have quietly racked up 16 straight days of inflows totaling $420.4 million, signaling allocators rotating toward higher-yielding altcoin exposure rather than exiting crypto entirely.

AGING AS A DISEASE: THE RISE OF LONGEVITY SCIENCE

The frontier of medicine is shifting from fighting disease to pursuing more life. Speakers at the recent Progress Conference 2025 held at Lighthaven spoke about extending life by addressing the biological hallmarks of aging itself: genomic instability, telomere shortening, mitochondrial dysfunction, and cellular senescence. The new frontier is to find targeted interventions that impact these factors. The pursuit of longevity, not survival, is still in its early days. Research is happening largely along non-traditional paths and with non-traditional funding and support models.

NEW NANOPARTICLE MRNA VACCINE MAY BE CHEAPER AND 100 TIMES MORE POWERFUL

Researchers at MIT have developed a new lipid nanoparticle that enhances the effectiveness of an mRNA vaccine by a hundred times compared to stand-alone effectiveness in mice. The system could be used to develop vaccines for a number of diseases, including COVID-19 and influenza. By increasing potency and reducing cost per dosage, the system could become an inexpensive way to combat many infectious diseases. It could also help improve the efficacy of some vaccines.

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