Daily Edition · Page 1

THE DAILY INDEX

Technology, AI, software, security, crypto and business

Across today’s newsletters

Today’s Index

SWEEPING DOJ MEMO SIGNALS TURNING POINT

A new memo from the DOJ signals a shift away from prosecuting crypto intermediaries, narrowing enforcement to clear cases of fraud or national security risk and potentially leading to the closure or dismissal of ongoing investigations launched under the Biden administration. While industry advocates see this as a relief, critics warn it may weaken oversight and embolden misconduct, with civil agencies like the SEC and CFTC also adjusting their approach in response.

MUSK'S SPACEX IS FRONTRUNNER TO BUILD TRUMP'S GOLDEN DOME MISSILE SHIELD

SpaceX and two partners, Anduril and Palantir, are frontrunners in a race to win a crucial part of President Trump's Golden Dome missile defense shield. They have proposed a constellation of 400 to more than 1,000 missile defense satellites and a subscription model for missile defense. Trump has cited a missile attack as the most catastrophic threat facing the US. The decision process for the Golden Dome is in its early stages and its ultimate structure and who is selected to work on it could change drastically in the coming months.

SUGAR

Orforglipron is a daily pill by Eli Lilly that may be as effective in lowering blood sugar and aiding weight loss in people with Type 2 diabetes as Ozempic. It is part of the GLP-1 class of drugs that have become famous for their weight-loss effects. While the pill is still expected to be expensive, it has the potential to become far more widely used than current GLP-1s, which must be kept refrigerated and must be injected. Eli Lilly will seek approval from the FDA later this year to market the drug for obesity and early in 2026 for diabetes.

WORLD'S FIRST "NONSTOP BEATING HEART" TRANSPLANT IS A MEDICAL BREAKTHROUGH

Surgeons at the National Taiwan University Hospital have performed a heart transplant during which the donor's heart continued beating between the organ removal and transplantation stages. Donor hearts are usually removed and preserved in cold storage, which can damage muscle tissue, reducing function and health once transplanted. The operation was possible due to a specially designed organ maintenance system that kept the donor heart pumping with oxygenated blood throughout the process. Followup appointments with the patient showed that they maintain a low level of cardiac enzyme, something that usually spikes during typical transplant conditions.

A PRACTICAL GUIDE TO BUILDING AGENTS

Agents are AI systems that can perform workflows on users' behalf with a high degree of independence. This guide, designed for product and engineering teams, explores how to build agents with frameworks for identifying promise use cases, clear patterns for designing agent logic and orchestration, and best practices to ensure agents run safely, predictably, and effectively. It provides the foundational knowledge needed to confidently start building agents. Building reliable agents means starting with strong foundations - start small, validate with real users, and grow capabilities over time.

TLDR IndexPage 1