OTOF-related hearing loss results from a genetic change in a single critical protein. The auditory nerve fails to receive the proper signals from the hair cells in the ear due to the lack of the proper protein, resulting in profound deafness. DB-OTO is a virus-based gene therapy that can deliver a working version of the OTOF gene. It uses a non-pathogenic virus to carry the proper genetic code that produces the protein. In an early trial of the DB-OTO treatment, eleven out of twelve patients developed improved hearing within weeks, and nine patients no longer required cochlear implants.
55% of knowledge workers are putting in more hours but delivering less. The culprit? Well over half say that fragmentation is a productivity killer. Miro's 2025 Momentum at Work Report [9] lays out the costs of tool sprawl and the solutions that get teams back on
Model choice matters for extremely long-running tasks. GPT-5.2 models perform better at extended autonomous work compared to Opus 4.5 and GPT-5.1-codex. Many improvements come from removing complexity rather than adding it. The best system is often simpler than you'd expect. The harness and models matter, but the prompts matter more.
The most compelling reason to hire juniors is AI itself. The biggest barrier to AI transformation has been workforce buy-in. Gen Z leads in AI adoption, and they act as an accelerant, helping colleagues learn AI tools and workflows. AI has lowered the cost of onboarding. If the infrastructure already exists, hiring juniors may be one of the highest-leverage AI bets available today.
Long-horizon agents allow models to take actions and iterate over time. The rate of progress in this area of research is exponential. It is estimated that agents will be able to work reliably to complete tasks comparably to human experts by 2028. People will soon be able to hire agents - one of the litmus tests for AGI.
Humans will lose control over the future if AI capabilities continue to advance. However, if we manage to avoid that, there's a good chance humans will retain a lot of employment during the Cyborg Era, which might last around 10 to 20 years. It is implausible that AI capabilities and available compute continue to increase indefinitely. This is a transitional state.
Anthropic blocking third parties from using the Claude Code API will not convert people back to Claude Code, it will just convert people to other model providers.
This post presents a list of terms used in Gas Town, an AI agent orchestration tool, decoding the definitions used in the introductory paper for developers.
Apple recently announced that it had decided to rely on Gemini to power its AI features. The company will be able to fine-tune the model so that it responds in Apple's preferred manner. Apple's AI won't respond with any branding related to Google or Gemini. Some of the features will launch this spring. More advanced features are expected to be announced at Apple's annual developer conference in June.
Meta and EssilorLuxottica are discussing potentially doubling production capacity to 20 million units or more by the end of the year to capture growing demand and head off rivals. They may potentially further establish the capability of producing more than 30 million units if demand justifies such a move. No final decisions have been made yet. The talks signal confidence that smart glasses can move beyond early adopters and reach mass-market scale.
China's Institute of Radio Spectrum Utilization and Technological Innovation has filed a request with the International Telecommunications Union to operate a satellite constellation with a total of 193,428 satellites. The request far exceeds the ambitions of other current constellation projects. The Chinese constellations plan to use a wide range of radio frequencies and will be deployed across numerous orbits from 300 to 600 kilometers, as well as higher objects at around 20,000 kilometers. The US Federal Communications Commission views China's satellite ambitions as a national security threat.
Reports from a supply chain leaker indicate that OpenAI's first AI gadget is aimed at taking on Apple's AirPods. The device, codenamed 'Sweetpea', is an audio product that resembles an earpiece. It is projected to be released around September. OpenAI has other hardware in the works, including a home-style device and a pen.
Ramp [8] adopted the Builder mindset and an ambitious plan: to become the most productive company in the world. So far, they shipped 270 features in H1 2025 (MORE THAN ALL OF 2024 combined), and 90% of 1,200 employees use Notion AI monthly. Read more on the Notion blog [8] →
Smart specs guide agents clearly, stay within practical context sizes, and evolve with projects. Aim to create clear specs that cover just enough nuance to guide the AI without overwhelming it. Break large tasks into smaller ones. Plan first in read-only mode before executing, and iterate continuously. This post presents a framework for spec-writing that keeps AI agents focused and productive.
Google deprecated JPEG-XL support in Chrome/Chromium back in 2022. The decision was widely criticized, and Google said that it may reconsider. The code to restore support was merged this week, so JPEG-XL image support is back in the very latest Google Chrome/Chromium codebase.
AI should be part of every process, but the final filter must be human judgment informed by taste. The hardest decisions aren't reducible to rules. AI can tell you whether something works, but only taste can tell you whether it belongs. Personal taste is the moat when execution is cheap and correctness is abundant.
The tech world is moving towards voice-powered computing. Several companies are building purpose-built hardware for AI that will be predominantly controlled via voice. This will help set up the next wave of technology: robots. Robots will be wholly voice-controlled.
The partnership gives Apple time to manage expectations across its platforms as it develops its own in-house AI server chips, expected to enter mass production in the second half of 2026.
Today's masses still have power due to their labor contribution and their ability to physically rebel against the elite, but AI has the potential to change that power balance.
Apple and Google have formed a multiyear partnership to power Apple's AI features with Google's Gemini model. Apple's future foundation models will lean on Google's cloud technology. Models will continue to run on Apple devices and the company's private cloud compute. The terms of the deal have not been made public, but in August, Apple was reportedly planning to pay about $1 billion a year to utilize Google's AI.
Meta Compute is a new initiative by Meta aimed at securing the enormous amounts of computing power the company's AI models need. Meta plans to build tens of gigawatts this decade as it races to develop superhuman untell agency. The company named Dina Powell McCormick as the new president and vice chair on Monday. Powell McCormick will work on developing partnerships with governments to finance and deploy data centers across the world.
Nvidia plans to invest $1 billion over five years in a new laboratory with Eli Lilly. The facility, to be built in Silicon Valley, will bring Lilly's lab expertise close to the center of AI innovation. It will help AI engineers learn what it takes to run lab equipment and research tasks. Nvidia plans to make its suite of AI models and agents tailored for the healthcare industry open source, so anyone will be able to tinker with the technology and adapt it to their needs.
1X has integrated its new video-pretrained world model, 1XWM, into its NEO robot platform. The 1XWM model predicts robot actions by generating text-conditioned video rollouts and then translating them into motion commands through an Inverse Dynamics Model. It uses a 14B parameter generative video model as a backbone, with inference currently taking about 11 seconds per rollout. The method enables faster adaptation to new tasks as it doesn't require tens of thousands of robot demonstration hours.
TLDR puts you in front of your target audience with almost no competition. Each issue features only three advertisers max, giving your message the space it needs to stand out. Millions of developers, product managers, CEOs, and other tech decision makers actually see what you have to say. Learn more [13] about running a test campaign.
Inspect is a coding agent that closes the loop on verifying its work by having all of the context and tools needed to prove it. It can run tests, review telemetry, and query feature flags, and it visually verifies its work and gives users screenshots and live previews. Each session runs in a sandboxed VM with everything an engineer would have locally. This post contains the spec for Inspect so anyone can replicate the tool.
Claude Cowork is a general agent with a UI now available as a research preview to Max subscribers as part of the updated Claude Desktop macOS application. It looks very similar to the desktop interface for regular Claude Code. The general agent is designed to bring the powerful capabilities of Claude Code to a wider audience with a less intimidating interface. Screenshots of the feature are available in the article.
We will still want human-sourced goods and services in the future. Humans have been shown to be incredibly creative when manufacturing scarcity for the purpose of playing status games. This ability is increasing, and the trend is accelerating. Humans will be able to create enough scarcity to employ people to produce artisan goods.
This post contains a conversation between Michael Burry, Dwarkesh Patel, Patrick McKenzie, and Jack Clark on the AI revolution and its impact on the economy. Burry, who called the subprime mortgage crisis when everyone else was buying in, is skeptical of the trillions powering into AI infrastructure. Clark is one of Anthropic's co-founders, and McKenzie and Patel have interviewed many people across the industry.
Engineers make the right observations, make the right decisions, and take the right actions, in the right sequence, to accomplish the right intentions.
AI is all the rage, but are you really using it to your advantage? This practical guide [4] from You.com [4] guides you through the process of identifying and prioritizing opportunities where AI can best serve your org. Explore where AI can drive the most impact in your organization, both internally and externally.
Google has unveiled a new set of tools for retailers to help them roll out AI agents. The new retail AI agents can help shoppers find their desired items and provide customer support. They are designed to address the challenges retailers face in building their own AI agents. Major retailers, including Lowe's and Kroger, are already using Google's tools.
Sportscaster Bill Simmons will go live on Netflix on Sunday night, marking the unofficial beginning of Netflix's move into podcasting. Netflix plans to offer dozens of podcasts over the next few months. It is a big moment for the podcasting industry, which is praying that Netflix will turn into a major new buyer.
SpaceX's plan to upgrade Starlink with gigabit internet speeds has received partial approval from the US FCC. The company can now launch 7,500 more satellites, operate its constellation at lower orbits, and use a larger swath of radio frequencies. SpaceX has received a time-limited waiver to operate the Starlink network at higher power levels to improve speeds. The waiver is confined to Starlink operations in the US.