TEAM USES ALPHAFOLD AI TO REDESIGN GENE-EDITING PROTEINS TO MAKE THEM SAFER

Summary from the TLDR newsletter

A team based in China modified AlphaFold to help identify what parts of a gene-editing protein enable mistakes. They then modified these areas to reduce problematic off-target effects. Producing gene-editing systems tailored to prevent known off-target events is useful for fine-tuning protein-DNA interactions, which could have applications beyond gene editing.