NEW FRONTIER MODELS ARE FASTER, NOT MORE RELIABLE, AT SPATIAL BIOLOGY

Summary from the TLDR AI newsletter

GPT-5.5 nearly halves runtime on SpatialBench relative to GPT-5.4, but its accuracy remains about the same. Opus 4.7 is similarly tied with Opus 4.6. Improvements and spatial biology are unlikely to come from general reasoning gains alone. It will likely require explicit training on statistical design, platform-specific analysis stems, replicate-aware differential testing, and other spatial biology knowledge.