SOME CASES OF ALZHEIMER'S CAUSED BY TWO COPIES OF A SINGLE GENE

Summary from the TLDR newsletter

Researchers have identified a genetic form of late-in-life Alzheimer's disease that occurs in people who inherit two copies of the APOE4 gene. The gene has been associated with the disease as a risk factor for Alzheimer's for years. A recent study suggests that having two copies of the gene is an underlying cause of Alzheimer's rather than just a risk factor. An estimated 15% of Alzheimer's patients carry two copies of APOE4. The gene can make symptoms begin seven to 10 years sooner than in other adults, but it also makes patients more prone to the dangerous side effects of some drug treatments. The discovery allows researchers to develop gene therapy or drugs specifically targeting the gene.