GENERALIZED BIOMOLECULAR MODELING AND DESIGN WITH ROSETTAFOLD ALL-ATOM

Summary from the TLDR AI newsletter

Advances in AI, including AlphaFold, have significantly increased the rate of progress in science. This study presents RoseTTAFold All-Atom, a neural network that can model a wide range of molecules beyond proteins including drugs, vitamins, DNA, and sugars. The authors validate their architecture by fine-tuning it into a diffusion model and experimentally validating new-to-nature molecules designed from minimal prompts across many applications.