THERE’S NO SUCH THING AS A DESKTOP SCREEN

Summary from the TLDR Design newsletter

A high-quality web UI is, among other things, extremely robust. It manages to convey information with consistency regardless of the viewport size (down to a reasonable limit) or font size preferences. Many factors influence this, including zoom, window size, font size, and arbitrary user-inflicted stylesheets. In CSS, text-relative units should be used everywhere, including the media queries.